[DCD-1]: Found in sweat, has an antimicrobial activity during early bacterial colonization . The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes . Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival . Highly effective against E.coli, E.faecalis, S.aureus and C.albicans . Optimal pH and salt concentration resemble the conditions in sweat . Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues . ; [Survival-promoting peptide]: Promotes survival of neurons and displays phosphatase activity . It may bind IgG .
Secreted .; [Survival-promoting peptide]: Secreted .; [DCD-1]: Secreted . Membrane ; Peripheral membrane protein . Membrane ; Single-pass membrane protein . The secreted peptide assembles into homohexameric complexes that can probably associate with pathogen membranes and also insert into these membranes where they behave as channels. .
Specifically and constitutively expressed in eccrine sweat gland cells (at protein level). Secreted into the sweat at a concentration of 1-10 micrograms/ml.
下载说明书
