Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.
Cytoplasm, perinuclear region . Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Expressed in neuronal cell bodies and axonal fibers. .
Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level).
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