Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling . May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly .
Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell junction, focal adhesion . Cell projection, neuron projection . Cell projection, axon . In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. .
Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus (PubMed:12034507). Expressed in podocytes (at protein level) (PubMed:29058690).
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