Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner . Modulates KCND3/Kv4.3 currents . Isoform 4 does not increase KCND2 expression at the cell membrane . Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
Cell membrane ; Peripheral membrane protein . Cytoplasm .; [Isoform 4]: Endoplasmic reticulum .
Predominantly expressed in brain.
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