Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol . Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) . Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA . Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation . ; [Isoform 2]: Sulfonates pregnenolone but not cholesterol.
Cytoplasm, cytosol . Microsome . Nucleus . Phosphorylation of Ser-348 is required for translocation to the nucleus. .
Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level) (PubMed:28575648). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung (PubMed:9799594).
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