Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization . Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration . May enhance calcium influx through CACNA1E and stimulate programmed cell death .
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole .
Widely expressed. Not detected in lymphocytes.
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