[DAP3-binding cell death enhancer 1]: Key activator of the integrated stress response (ISR) following mitochondrial stress . In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR . Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation . ; [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI . It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR .
[DAP3-binding cell death enhancer 1]: Mitochondrion . Mitochondrion inner membrane . Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1). .; [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol . This short form is generated by proteolytic processing by OMA1 in response to mitochondrial stress, leading to translocation to the cytosol. .
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
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