May function in protein sorting in late endosomes or multivesucular bodies (MVBs). ; (Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV).
Golgi apparatus membrane ; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle membrane ; Peripheral membrane protein. Endosome membrane ; Peripheral membrane protein. Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915).
Expressed in all but one (skeletal muscle) tissues examined.
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