Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain.
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