Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit . Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL . Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity).
Nucleus, nucleolus . Nucleus . Nucleolar location depends on active PolI transcription of pre-rRNA. .
下载说明书
