Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass type II membrane protein . Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. .; [Isoform 2]: Secreted .
The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta.
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