Involved in redox regulation of the cell . Acts as an antioxidant . Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation . May affect bone resorption and help to maintain bone mass . Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway .
Cytoplasm . Secreted . Secreted from mature adipocytes but not from preadipocytes. .
Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).
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