May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation . May also regulate the SLC18A3 and SLC5A7 cholinergic transporters .
Cytoplasm . Golgi apparatus .
Ubiquitous.
下载说明书
