Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress . Binds to double-stranded RNA or DNA without sequence specificity . Involved in development of the eye and of primordial germ cells (By similarity).
Nucleus, nucleolus . Nucleus, nucleoplasm . Chromosome . Localizes predominantly in the nucleolus with minor punctate signals in the nucleoplasm. .
Widely expressed.
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