Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum . Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear . Undergoes both rapid and slow structural rearrangements in response to changes in voltage . Contains a zinc-binding site that can regulate the slow conformational transition .
Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Perikaryon . Present in the dendrites and soma of cerebellar granule neurons, but not in their axon. .
Mainly expressed in the cerebellum (PubMed:25165868). Also expressed in cerebral cortex, skeletal muscle and thyroid, but at much lower levels (PubMed:25165868).
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