Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation . May be involved in Golgi homeostasis .
Endosome . Lysosome . Endoplasmic reticulum-Golgi intermediate compartment . Cytoplasmic vesicle, COPI-coated vesicle . Endoplasmic reticulum .
Expressed throughout the brain.
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