Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation . May be required for proper maturation and function of a subset of inhibitory synapses (By similarity).
Cytoplasm . Cell junction, synapse, postsynaptic density . Cell projection, dendrite . Basal cell membrane . Cell junction, synapse, postsynapse . Nucleus . Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells. .
Highly expressed in brain, kidney and pancreas.
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