Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size . Required for secretion of extracellular matrix proteins . Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors . Acts as a regulator of the unfolded protein response (UPR) (By similarity).
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Highest levels in heart, skeletal muscle, and kidney.
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