Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.
Cell membrane ; Multi-pass membrane protein . Localized at the brush border membranes of the proximal tubules.
Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.
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