Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes . PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer . In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons . Plays an indirect role in the regulation of cell morphology and cytoskeletal organization . May inhibit herpes simplex virus 1 infection at an early stage .
Endoplasmic reticulum membrane ; Single-pass membrane protein . Localizes at mitochondria-endoplasmic reticulum contact sites. .
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