Chromatin-associated factor that regulates transcription . Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription . Regulates the epigenetic status of rDNA .
Nucleus . Nucleus, nucleolus . Chromosome . Associates with chromatin regions of rDNA. .
High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung.
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