Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner . Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates .
Endoplasmic reticulum membrane ; Multi-pass membrane protein ; Lumenal side .
Widely expressed. In the eye, abundant in the retinal pigment epithelium.
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