Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity . Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) . Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4.
Nucleus .
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