Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi .
Endoplasmic reticulum membrane ; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle . Enriched at the endoplasmic reticulum exit sites (By similarity). Incorporated into COPII-coated vesicles (By similarity). .
Ubiquitously expressed with abundant expression in pancreatic tissue, islets, beta cells, and brain. Highly expressed in coronary smooth muscles.
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