The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
Cytoplasm . Membrane .
Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.