Involved in pre-mRNA splicing as a component of the spliceosome . Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK . Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). ; (Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
Cytoplasm . Nucleus . Nucleus speckle . Colocalizes with SRSF1 in nuclear speckles. .
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