Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether . TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis . Modulates YAP1 activity as transcriptional regulator .
Cytoplasm, cytoskeleton, spindle . Vesicle . Midbody . Cytoplasm . During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission (PubMed:30715179). Colocalizes with RAB3IP on preciliary vesicles (PubMed:31467083). .
Broadly expressed. High levels in brain, cerebellum, testis and whole blood.
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