Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids . Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria . Negatively regulates lipid droplet size and motility . Required for efficient lysosomal protein degradation .
Mitochondrion outer membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Lipid droplet . Golgi apparatus . Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle . Localizes at mitochondria-endosomes and mitochondria-endoplasmic reticulum contact sites (PubMed:30741634, PubMed:30709847, PubMed:30093493). .
Expressed in red blood cells (at protein level) (PubMed:31086825). Widely expressed, with high expression in brain, heart, skeletal muscle and kidney (PubMed:15498460).
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