Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
Nucleus . Chromosome, centromere, kinetochore . Associated with the kinetochore.
Highest levels of expression in heart and skeletal muscle, with significant levels expressed in kidney and liver.
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