Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity.
Sarcoplasmic reticulum membrane . Endoplasmic reticulum membrane . Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes. .
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