Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).
Cytoplasm, cytoskeleton . Cytoplasm . Nucleus . Early endosome . Early endosome membrane . Cell projection, ruffle membrane . Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. .
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