E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation . May play a role in the acrosome reaction and fertilization.
Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . Cytoplasm, cytoskeleton . Found in the acrosomal region of elongated spermatids and mature sperm. .
Highly expressed in testis, prostate and brain (PubMed:15145053). Weakly expressed in kidney, lung and heart (PubMed:15145053). Expressed in fetal tissues (PubMed:28087737).
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