Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Endoplasmic reticulum lumen . Endoplasmic reticulum-Golgi intermediate compartment .
Higher levels in kidney, pancreas, heart, and skeletal muscle.
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