Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Late endosome membrane ; Peripheral membrane protein . Recruited to the endosomal membrane in a VPS4A-dependent fashion.
Widely expressed. Expressed in macrophages and lymphocytes.
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