Involved in the negative regulation of p53 expression . Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins . Mediates MAPK14 dephosphorylation and inactivation . Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).
Nucleus . Cytoplasm, cytosol .
Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
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