Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Cytoplasm, perinuclear region . Cell membrane .
Expressed in all cardiac subcompartments and in the brain, with highest levels in the atrioventricular node and brain.
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