E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins . May operate on tyrosine-phosphorylated SRC substrates .
Cytoplasm . Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail. .
Exclusively expressed in testis and sperm, including spermatocytes, round and elongated spermatids, and Leydig cells.
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