In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption . ; [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.
Cytoplasm, cytoskeleton . Cell projection, axon . Cell membrane, sarcolemma . Cell junction, synapse, postsynaptic cell membrane . Lysosome . Cell membrane, sarcolemma, T-tubule . In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes. .; [Isoform 5]: Cytoplasm, cytoskeleton . Golgi apparatus .
Expressed in brain, neurons, muscles and other tissues.
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