Protein that plays a role in the inhibition of canonical Wnt signaling pathway . May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length .
Cell projection, cilium . Cytoplasm, cytoskeleton, cilium axoneme . Cell projection, kinocilium . Cytoplasm, cytoskeleton . Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner. .
Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus (PubMed:10601354, PubMed:16278297). Expressed in liver by cholangiocytes, the epithelial cells of the bile ducts (at protein level) (PubMed:27319779).
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