Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro .
Cytoplasm, cytoskeleton . Cytoplasm . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle . Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). .
Expressed in testis, restricted to Sertoli cells (at protein level).
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