Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell . This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments . The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) . Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
Cytoplasm, cytosol . Golgi apparatus membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane . Cell membrane . Early endosome membrane . Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1 (PubMed:12324459). Association with early endosomes has not been confirmed (PubMed:11923287, PubMed:12324459). .
Widely expressed.
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