May play a role in cholesterol transfer to late endosomes . May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation .
Membrane ; Single-pass type III membrane protein . Late endosome membrane . Membrane raft . Cell membrane ; Single-pass type III membrane protein. Cytoplasmic vesicle .
Ubiquitously expressed at low levels. Expression is highest in brain.
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