[Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates . Preferentially activated by Ca(2+) over Mg(2+) . ; [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally.
[Isoform 1]: Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein.; [Isoform 2]: Golgi apparatus membrane ; Multi-pass membrane protein .
Ubiquitous. Highest expression in testis and lowest in bladder.
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