Serine peptidase whose precise substrate specificity remains unclear . Does not cleave peptides after a arginine or lysine residue . Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex . May play a role in the regulation of synaptic vesicle exocytosis .
Cytoplasm, cytosol . Golgi apparatus, trans-Golgi network . Cytoplasm, cytoskeleton . Golgi apparatus . Nucleus . Co-localizes with AP-1 in the trans-Golgi network (By similarity). Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity). Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity). .
Expressed in pyramidal neurons of the temporal cortex and neocortex (at protein level) (PubMed:23485813). Widely expressed (PubMed:15913950, PubMed:16385448). Expressed at higher level in brain, skeletal muscle, heart and kidney (PubMed:15913950, PubMed:16385448). Expressed at the endplates in the neuromuscular junction (PubMed:24610330).
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