Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA . Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes .
Cytoplasm .
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