Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity . Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
Cytoplasm . Cell junction, synapse . Nucleus . Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). .
Detected in umbilical vein endothelial cells.
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