[Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
Cell membrane ; Single-pass type I membrane protein . Peroxisome membrane ; Single-pass type I membrane protein . Imported in peroxisomes through the PEX5 receptor pathway. .; [Irisin]: Secreted. Detected in the blood of individuals subjected to endurance exercise. .
Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.
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