Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. ; Plays a role as an effector in the TP53-dependent apoptotic pathway.
Cell junction, desmosome . Cell membrane ; Multi-pass membrane protein . Associated with desmosomes (By similarity). Colocalizes with KRT14 in the cell membrane (PubMed:31898316). .
Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.
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