BAP1 (Phospho Ser592) rabbit pAb

catalytic activity:Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).,disease:Defects in BAP1 are found in non-small cell lung cancer (NSCLC) cell lines.,disease:Tumor-associated antigen found in several childhood medulloblastoma.,function:Deubiquitinating enzyme which may be involved in BRCA1 signal transduction pathway.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C12 family.,subunit:Interacts with the RING finger domain of BRCA1.,tissue specificity:Highly expressed in testis, placenta and ovary. Expressed in breast.,