function:Actin-binding protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.,PTM:Phosphorylated.,PTM:The N-terminus is blocked.,similarity:Contains 2 actin-binding domains.,similarity:Contains 2 EF-hand domains.,similarity:Contains 4 CH (calponin-homology) domains.,subunit:Monomer.,tissue specificity:Restricted to the spleen and other lymph node-containing organs. Expressed in neutrophils, monocytes, B lymphocytes, and myeloid cells.,
Cytoplasm, cytoskeleton . Cell junction . Cell projection . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation (PubMed:16636079). .
Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
下载说明书
